Abstract NLRP3 induces caspase-1-dependent pyroptotic cell death to drive inflammation.Aberrant activity of NLRP3 occurs in many human diseases.NLRP3 activation induces ASC polymerization into a single, micron-scale perinuclear punctum.Higher resolution imaging of this signaling platform is needed to understand how it induces pyroptosis.Here, we ap
Near-term climate predictions such as decadal climate forecasts are increasingly being used to guide adaptation measures.For near-term probabilistic predictions to be useful, systematic errors of the forecasting systems have to be corrected.While methods for the calibration of probabilistic forecasts are readily available, these have to be adapted
This article examines the archaeological Lighting Incandescent finds from the last quarter of the thirteenth and fourteenth century, which shed light on the history of mediaeval Chersonese (Cherson).After the catastrophe that Cherson experienced in the third quarter of the thirteenth century, the urban settlement continued existing.The arguments ar
Objective: To see the long and short term outcome of the Gastrocnemius muscle flap for coverage of soft tissue defects of knee and Ducted System proximal Tibia.Study Design: Case series.Place and Duration of Study: Surgery Department of Combined Military Hospital Bahawalpur, from Dec 2014 to Oct 2017.Methodology: A total of 33 patients were enrolle
Surgery as an art in rhinoplasty involves grafting techniques wherein materials (usually autologous) are taken from the septum and supplemented by conchal cartilage.However, not all noses have adequate cartilage material.The quest for materials as possible replacement for human tissue have led to invention of synthetic (e.g.silicone, Mountaineering